The alphamegalog of the cities of Mississippi lists the largest city in Mississippi for each letter of the alphabet. In this case, ‘largest’ is based on population within the city proper.

Amory
Biloxi
Clinton
D’Iberville
Ellisville
Flowood
Gulfport
Hattiesburg
Indianola
Jackson
Kosciusko
Laurel
Meridian
Natchez
Olver Branch
Pearl
Quitman
Ridgeland
Southaven
Tupelo
University
Vicksburg
West Point
(no X)
Yazoo City
(no Z)