The alphamegalog of Central American cities lists the largest city within the countries of Central America for each letter of the alphabet. In this case, ‘largest’ is based on population within the city proper.

Alajuela, Costa Rica
Bilwi, Nicaragua
Cobán, Guatemala
David, Panama
El Progreso, Honduras
Flores, Costa Rica
Guatemala City, Guatemala
Heredia, Costa Rica
Ilopango, El Salvador
Jinotega, Nicaragua
Kusapin, Panama
La Ceiba, Honduras
Managua, Nicaragua
Nueva Guinea, Nicaragua
Olanchito, Honduras
Panama City, Panama
Quetzaltenango, Guatemala
Rivas, Nicaragua
San Pedro Sula, Honduras
Tegucigalpa, Honduras
Usulutan, El Salvador
Villa Nueva, Guatemala
Waslala, Nicaragua
Xaibe, Belize
Yalagüina, Nicaragua
Zacatecoluca, El Salvador