The alphamegalog of Canadian cities lists the largest city in Canada for each letter of the alphabet. In this case, ‘largest’ is based on population within the city proper.

Abbotsford, British Columbia  
Brampton, Ontario
Calgary, Alberta
Delta, British Columbia
Edmonton, Alberta
Fredericton, New Brunswick
Gatineau, Quebec
Hamilton, Ontario
Innisfil, Ontario
Joliet, Quebec
Kitchener, Ontario
London, Ontario
Montreal, Quebec
North Vancouver, British Columbia
Ottawa, Ontario
Peterboro, Ontario
Quebec City, Quebec
Regina, Saskatchewan
Surrey, British Columbia
Toronto, Ontario
Ucluelet, British Columbia
Vancouver, British Columbia
Winnipeg, Manitoba
(no X)
Yorkton, Saskatchewan
(no Z)