The alphamegalog of the cities of West Virginia lists the largest city in West Virginia for each letter of the alphabet. In this case, ‘largest’ is based on population within the city proper.

Alum Creek
Beckley
Charleston
Dunbar
Elkins
Fairmont
Grafton
Huntington
Inwood
Jefferson
Kaiser
Lewisburg
Morgantown
Nitro
Oak Hill
Parkersburg
Quinwood
Ranson
South Charleston
Teays Valley
Upper Falls
Vienna
Wheeling
(no X)
(no Y)
(no Z)